Immunomodulatory, cytotoxic and antileishmanial activity of phytoconstituents of Croton zambesicus
نویسندگان
چکیده
The root extract and fractions of Croton zambesicus were investigated for anticancer activity against HeLa cells, DNA interaction, immunomodulatory and antileishmanial activities. The GCMS analysis of the most active fraction against HeLa cell was carried. The root extract was found to exert significant anticancer activity with the hexane fraction exhibiting the most pronounced effect. The crude extract and the fractions did not interact with yeast DNA when investigated using electrophoresis. The extract demonstrated prominent antioxidant activity in whole blood, neutrophils and macrophages. The extract also exhibited moderate antileishmanial activity against promastigotes of Leishmania major in vitro. These results suggest that the root extract/fractions of croton zambesicus possesses anticancer, immunomodulatory and antileishmanial activities and these justify its use in ethnomedicine to treat cancer and microbial infections and can be exploited in primary healthcare.
منابع مشابه
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